Taxus plant suspension cultures can be used to produce paclitaxel, an anticancer compound. Currently PTX is administered systemically, which can have severe side effects. To minimize these effects, this project investigates the use of a plant cell culture (PCC) delivery system for paclitaxel through exploring retention of paclitaxel and other specialized metabolites through PCC processing, optimization of drug delivery through various polymers, predicted release in an in vitro breast cancer model, and consideration of the pharmacokinetics of the optimized system.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Johnson, Michaela Faith
• Thurlow, Summer L.
• Rivers, Jason B.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051620-041057

Advisor

• Coburn, Jeannine M
• Roberts, Susan Celia

Year

• 2020

Date created

• 2020-05-16

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright

Última modificação

• 2020-11-20