Scientists have identified a total of 24 argonautes in C. elegans. However, there is still uncertainty as to the specific function of some of these worm-specific argonautes and the question remains as to which secondary argonautes are involved in the ALG-3/4 pathway and can the method for how they regulate their targets be uncovered. From male and sperm gene expression datasets, we have identified candidate secondary Argonautes that could be involved in the downstream function of the ALG-3/4 pathway (Unpublished data, Mello Lab). Here we report that the addition of the genetic mutants wago-1, wago-9, and wago-10 produce significantly lower broods and their compounded effect can be seen in the overall phenotype of the worm.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Kashmanian, Paul Louis

Contributori

• Huseby, Eric

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042413-105636

Advisor

• Heilman, Destin

Year

• 2013

Sponsor

• UMass Medical School

Date created

• 2013-04-24

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright