Student Work

A Motorized Micro-Punch for Pancreatic Islet Isolation in Diabetes Research

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Islets of Langerhans are clusters of cells in the pancreas that regulate blood glucose levels. There are four main constituents of an islet: α cells, β cells, ઠ cells, and pancreatic polypeptide (PP) cells. These cells, scattered throughout the cluster, produce and release hormones for maintaining glucose homeostasis. Diabetes pathogenesis is complex and is often linked to the morphological changes in these islets, which makes islet cell isolation a crucial process in advancing diabetes research. To increase the throughput of viable islet recovery during the islet cell isolation process, a motorized micro-punch assembly was devised. This project was an extension of the manual micro-punch, where the cutting (twisting) motion of the former was changed to a punching motion that will increase the accuracy and the precision of the process.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • 71621
  • E-project-080822-224026
Keyword
Advisor
Year
  • 2022
Sponsor
Date created
  • 2022-08-08
Resource type
Major
Source
  • E-project-080822-224026
Rights statement
Last modified
  • 2022-12-16

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