Student Work
Evaluation of an Immobilized Transaminase for Preparation of an Intermediate to Glasdegib
公开 Deposited可下载的内容
open in viewerThe student worked with Pfizer Inc. to study the feasibility of an immobilized enzyme in the preparation of an intermediate to Glasdegib, a Phase I clinical SMO inhibitor that has shown promise in the inhibition of tumor growth for human colorectal and pancreatic cancers. The project resulted in an optimization of one immobilized resin based on the activity of the enzyme, enzyme stability in organic solvents, and reuse of the biocatalyst as well as apreliminary scale-up study utilizing AspenPlus.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042616-191118
- Advisor
- Year
- 2016
- Sponsor
- Date created
- 4016-04-26
- Resource type
- Major
- Source
- E-project-042616-191118
- Rights statement
- 最新修改
- 2024-05-13
关系
- 属于 Collection:
项目
单件
缩略图 | 标题 | 公开度 | Embargo Release Date | 行动 |
---|---|---|---|---|
Evaluation_of_an_Immobilized_Transaminase_for_Preparation_of_an_Intermediate_to_Glasdegib_Confidential_Submittal.pdf | 公开 | 下载 |
Permanent link to this page: https://digital.wpi.edu/show/0c483q072