Prostate cancer is projected to account for 27,000 deaths in the U.S. in 2007 (Jemal et al, 2007). Although much research has been conducted, the exact mechanisms of prostate cancer initiation and development are unknown. This MQP assessed the development of prostatic intraepithelial neoplasia (PIN) and adenocarcinoma, versus the expression of alpha V beta 6 integrin which has previously been implicated in other types of cancer signaling, at different time points in the specific background of PTEN-null mice, a model for prostate cancer. It was determined that integrin alpha V beta 6 was expressed in some stages of both PIN and adenocarcinoma.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sansoucy, Brian G

Contributors

• Languino, Lucia R.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-010308-234631

Advisor

• Adams, David S.

Year

• 2008

Sponsor

• University of Massachusetts Medical School

Date created

• 2008-01-03

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2023-10-06