PTEN is a novel tumor suppressor gene that is deleted in 70% of glioblastomas. Using rtPCR, western blotting, immunocytochemistry, and immunoprecipitations, we studied the expression of PTEN in rat glioma and pheochromocytoma and human glioblastoma, cell lines. Our results suggest that lack of PTEN protein may be involved in the tumorigenicity of these cell lines.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Nabi, Roya Renee

Publisher

• Worcester Polytechnic Institute

Identifier

• 99D158M

Advisor

• Ryder, Elizabeth F.

Year

• 1999

Date created

• 1999-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright