Characterization of Poxvirus A51 Protein Using Yeast-Two Hybrid Screening Public
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Lymantria dispar (Ld652) cells are normally resistant to infection by vesicular stomatitis virus (VSV), a simple RNA virus. However, when co-infected with vaccinia virus (VACV), a poxvirus used as a vaccine for smallpox, VSV is able to productively infect these cells. Previous work has shown that the sole factor responsible for this rescue of VSV by VACV is a highly conserved poxvirus protein known as A51, but the mechanism of this rescue is not currently understood. The mechanism behind this rescue was investigated using a yeast two-hybrid system to identify potential A51-binding proteins.
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