Atrial fibrillation (AF) is a troublesome disease often overlooked by more serious myocardial infarctions. Up until now, there has been very little or no use of high order spectral techniques in order to evaluate the organization of the atrium during AF. Cross-bicoherence algorithm can be used alongside a surrogate data threshold in order to determine significant phase coupling interactions, giving rise to an organizational metric. This proposed algorithm is used to show rotigaptide, a gap junction coupling drug, significantly increases the organization of the atria during episodes of AF due to improvement of cell-to-cell coupling.

Creator

• Jaimes, Rafael

Contributors

• Chon, Ki
• Granquist-Fraser, Domhnull
• McManus, David

Degree

• MS

Unit

• Biomedical Engineering

Publisher

• Worcester Polytechnic Institute

Language

• English

Identifier

• etd-051911-012047

Keyword

• cross-bicoherence
• atrial fibrillation
• cross-bispectrum
• high order spectral analysis
• cardiac electrophysiology
• surrogate data

Advisor

• Chon, Ki H.

Committee

• McManus, David
• Granquist-Fraser, Domhnull

Defense date

• 2011-05-19

Year

• 2011

Date created

• 2011-05-19

Resource type

• Thesis

Rights statement

• In Copyright