Although phosphatidylinositol (PI) and phosphoinositides (PIPs) only comprise a small percentage of the inner leaflet of the plasma membrane, they mediate a large variety of signaling events. In previous studies, we have observed the absence of macroscopically discernible domains in mixtures of PI/PC and PI(4,5)P2/PC. The addition of cholesterol to these mixtures results in condensation of the monolayer and hence domain formation. To better mimic the ionic conditions and hydrogen bonding properties of the inner leaflet plasma membrane, we investigated in this study the effect of common inner leaflet plasma membrane lipids like phosphatidylethanolamine (PE), phosphatidylserine (PS) and PI, on phosphoinositide domain behavior in the presence of cholesterol and/or bivalent cations.

Creator

• King, Katrice

贡献者

• Gericke, Arne

Degree

• PhD

Unit

• Chemistry & Biochemistry

Publisher

• Worcester Polytechnic Institute

Language

• English

Identifier

• etd-041916-215634

关键词

• phosphoinositides
• monolayer
• phospholipids
• plasma membrane
• phosphatidylinositol

Advisor

• Gericke, Arne

Defense date

• 2016-03-22

Year

• 2016

Date created

• 2016-04-19

Resource type

• Dissertation

Rights statement

• In Copyright